CAMK1

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.[5][6]

CAMK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDsOMIM: 604998 MGI: 1098535 HomoloGene: 117458 GeneCards: CAMK1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p25.3Start9,757,347 bp[1]
End9,769,992 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8536

52163

Ensembl

ENSG00000134072

ENSMUSG00000030272

UniProt

Q14012

Q91YS8

RefSeq (mRNA)

NM_003656

NM_133926

RefSeq (protein)

NP_003647
NP_003647.1

NP_598687

Location (UCSC)Chr 3: 9.76 – 9.77 MbChr 6: 113.33 – 113.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000134072 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030272 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.
  6. "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading


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