SNRK

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.[5][6][7]

SNRK
Identifiers
Aliases	SNRK, HSNFRK, SNF related kinase
External IDs	OMIM: 612760 MGI: 108104 HomoloGene: 9797 GeneCards: SNRK
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 43,286,512 bp[1] End 43,424,764 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 122,117,266 bp[2] End 122,169,702 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • ATP binding • magnesium ion binding • metal ion binding • kinase activity Cellular component • cytoplasm • cell nucleus Biological process • protein phosphorylation • myeloid cell differentiation • GO:0007243 intracellular signal transduction • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54861	20623
Ensembl	ENSG00000163788	ENSMUSG00000038145
UniProt	Q9NRH2	Q8VDU5
RefSeq (mRNA)	NM_001100594 NM_017719 NM_001330750	NM_001164572 NM_133741 NM_001357774 NM_001357775 NM_001357776
RefSeq (protein)	NP_001094064 NP_001317679 NP_060189	NP_001158044 NP_598502 NP_001344703 NP_001344704 NP_001344705
Location (UCSC)	Chr 3: 43.29 – 43.42 Mb	Chr 9: 122.12 – 122.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163788 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038145 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Becker W, Heukelbach J, Kentrup H, Joost HG (Jul 1996). "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases". Eur J Biochem. 235 (3): 736–43. doi:10.1111/j.1432-1033.1996.00736.x. PMID 8654423.
6. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
7. "Entrez Gene: SNRK SNF related kinase".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Iacobelli M, Wachsman W, McGuire KL (2000). "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein". J. Immunol. 165 (2): 860–8. doi:10.4049/jimmunol.165.2.860. PMID 10878360.
• Yoshida K, Yamada M, Nishio C, Konishi A, Hatanaka H (2000). "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons". Brain Res. 873 (2): 274–82. doi:10.1016/S0006-8993(00)02548-8. PMID 10930554.
• Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL (2002). "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions". J. Biol. Chem. 277 (38): 34967–77. doi:10.1074/jbc.M205048200. PMID 12087103.
• Kertesz N, Samson J, Debacker C, Wu H, Labastie MC (2003). "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases". Gene. 294 (1–2): 13–24. doi:10.1016/S0378-1119(02)00829-6. PMID 12234663.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR (2005). "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate". FEBS Lett. 579 (6): 1417–23. doi:10.1016/j.febslet.2005.01.042. PMID 15733851.