CDK12

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.[5][6][7] This enzyme is a member of cyclin-dependent kinase protein family.

CDK12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CXA, 4NST, 4UN0, 5ACB
Identifiers
Aliases	CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12
External IDs	OMIM: 615514 MGI: 1098802 HomoloGene: 128632 GeneCards: CDK12
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,461,486 bp[1] End 39,564,907 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.75 cM Start 98,203,059 bp[2] End 98,278,504 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • RNA polymerase II carboxy-terminal domain kinase activity • ATP binding • cyclin binding • cyclin-dependent protein serine/threonine kinase activity • transcription factor binding • protein kinase binding Cellular component • nuclear speck • nuclear cyclin-dependent protein kinase holoenzyme complex • cyclin K-CDK12 complex • cell nucleus • nucleoplasm • fibrillar center • chromosome • cyclin/CDK positive transcription elongation factor complex • cyclin-dependent protein kinase holoenzyme complex • nuclear chromatin Biological process • phosphorylation of RNA polymerase II C-terminal domain • phosphorylation • mRNA processing • regulation of cell cycle • protein phosphorylation • regulation of RNA splicing • RNA splicing • autophosphorylation • regulation of MAP kinase activity • transcription elongation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • negative regulation of stem cell differentiation • positive regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51755	69131
Ensembl	ENSG00000167258	ENSMUSG00000003119
UniProt	Q9NYV4	Q14AX6
RefSeq (mRNA)	NM_015083 NM_016507	NM_001109626 NM_001109628 NM_026952
RefSeq (protein)	NP_055898 NP_057591	NP_001103096 NP_001103098 NP_081228
Location (UCSC)	Chr 17: 39.46 – 39.56 Mb	Chr 11: 98.2 – 98.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000167258 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
6. Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles". J Cell Sci. 114 (Pt 14): 2591–603. PMID 11683387.
7. "Entrez Gene: CDK12 cyclin-dependent kinase 12".

External links

• Human CDK12 genome location and CDK12 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.