GNA11

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.[5][6] Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.[7]

GNA11
Identifiers
Aliases	GNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11
External IDs	OMIM: 139313 MGI: 95766 HomoloGene: 20474 GeneCards: GNA11
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,094,362 bp[1] End 3,123,999 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,528,724 bp[2] End 81,545,190 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • type 2A serotonin receptor binding • GTP binding • metal ion binding • guanyl nucleotide binding • G-protein coupled receptor binding • GTPase activity • signal transducer activity • G-protein beta/gamma-subunit complex binding • GO:0001948 protein binding Cellular component • cytoplasm • membrane • cell membrane • photoreceptor outer segment • lysosomal membrane • extracellular exosome • heterotrimeric G-protein complex Biological process • G-protein coupled acetylcholine receptor signaling pathway • skeletal system development • regulation of melanocyte differentiation • entrainment of circadian clock • platelet activation • heart development • cellular response to pH • phospholipase C-activating dopamine receptor signaling pathway • phototransduction, visible light • developmental pigmentation • action potential • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2767	14672
Ensembl	ENSG00000088256	ENSMUSG00000034781
UniProt	P29992	P21278
RefSeq (mRNA)	NM_002067	NM_010301
RefSeq (protein)	NP_002058	NP_034431
Location (UCSC)	Chr 19: 3.09 – 3.12 Mb	Chr 10: 81.53 – 81.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Gq alpha subunit

References

1. GRCh38: Ensembl release 89: ENSG00000088256 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034781 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014.
6. "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".
7. 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

Further reading

• Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
• Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575.
• Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312 (1): 151–8. doi:10.1042/bj3120151. PMC 1136238. PMID 7492305.
• Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C". J. Biol. Chem. 270 (25): 15175–80. doi:10.1074/jbc.270.25.15175. PMID 7797501.
• Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling". J. Biol. Chem. 270 (51): 30635–42. doi:10.1074/jbc.270.51.30635. PMID 8530500.
• Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
• Launay JM, Birraux G, Bondoux D, et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor". J. Biol. Chem. 271 (6): 3141–7. doi:10.1074/jbc.271.6.3141. PMID 8621713.
• Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318 (3): 1023–31. doi:10.1042/bj3181023. PMC 1217719. PMID 8836152.
• Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
• Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID 9175863.
• Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). "Activation of the prostaglandin FP receptor in human granulosa cells". J. Reprod. Fertil. 111 (2): 309–17. doi:10.1530/jrf.0.1110309. PMID 9462300.
• Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.
• Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11". Mol. Cell. Biol. 19 (1): 714–23. doi:10.1128/MCB.19.1.714. PMC 83928. PMID 9858594.
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.
• Brydon L, Roka F, Petit L, et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579.
• Corbetta S, Mantovani G, Lania A, et al. (2000). "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia". Clin. Endocrinol. 52 (3): 339–48. doi:10.1046/j.1365-2265.2000.00933.x. PMID 10718832.
• Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830.
• AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist". J. Biol. Chem. 276 (43): 39721–6. doi:10.1074/jbc.M105253200. PMID 11507095.