MAPK10

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[5][6][7]

MAPK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21
Identifiers
Aliases	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
External IDs	OMIM: 602897 MGI: 1346863 HomoloGene: 56439 GeneCards: MAPK10
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.3 Start 85,990,007 bp[1] End 86,594,625 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 102,907,948 bp[2] End 103,211,334 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • MAP kinase kinase activity • JUN kinase activity Cellular component • cytosol • membrane • mitochondrion • cell membrane • cell nucleus • cytoplasm • neuron projection • nucleoplasm • perikaryon • glutamatergic synapse • intracellular Biological process • phosphorylation • response to light stimulus • rhythmic process • Fc-epsilon receptor signaling pathway • protein phosphorylation • regulation of circadian rhythm • signal transduction • JUN phosphorylation • activation of MAPK activity • JNK cascade • regulation of gene expression • neuron development • GO:0007243 intracellular signal transduction • cellular response to organic substance • negative regulation of transcription from RNA polymerase II promoter • response to water deprivation • cellular hyperosmotic response • neurotransmitter receptor transport to postsynaptic membrane • vesicle-mediated transport in synapse • regulation of sequence-specific DNA binding transcription factor activity • MAPK cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5602	26414
Ensembl	ENSG00000109339	ENSMUSG00000046709
UniProt	P53779 Q499Y8	Q61831
RefSeq (mRNA)	NM_002753 NM_138980 NM_138981 NM_138982 NM_001318067 NM_001318068 NM_001318069 NM_001351624 NM_001351625 NM_001363657	NM_001081567 NM_009158 NM_001310683 NM_001310685 NM_001310686 NM_001318102 NM_001318131
RefSeq (protein)	NP_001304996 NP_001304997 NP_001304998 NP_002744 NP_620446 NP_620448 NP_001338553 NP_001338554 NP_001350586 NP_001304997.1	NP_001075036 NP_001297612 NP_001297614 NP_001297615 NP_001305031 NP_001305060 NP_033184
Location (UCSC)	Chr 4: 85.99 – 86.59 Mb	Chr 5: 102.91 – 103.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

MAPK10 has been shown to interact with MAPK8IP3.[8][9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000109339 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046709 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.
6. Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. doi:10.1007/s100380200094. PMID 12436199.
7. "Entrez Gene: MAPK10 mitogen-activated protein kinase 10".
8. Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
9. Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
10. Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. PMID 12189133.

Further reading

• Freedman BD, Liu QH, Del Corno M, Collman RG (2003). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res. 27 (2–3): 261–76. doi:10.1385/IR:27:2-3:261. PMID 12857973.
• Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
• Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991). "Phosphorylation of c-jun mediated by MAP kinases". Nature. 353 (6345): 670–4. doi:10.1038/353670a0. PMID 1922387.
• Mohit AA, Martin JH, Miller CA (1995). "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system". Neuron. 14 (1): 67–78. doi:10.1016/0896-6273(95)90241-4. PMID 7826642.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol. 27 (2): 397–404. doi:10.1002/eji.1830270209. PMID 9045910.
• Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature. 389 (6653): 865–70. doi:10.1038/39899. PMID 9349820.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu MC, Qiu WR, Wang YP (1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277–87. doi:10.1038/sj.onc.1201401. PMID 9393873.
• Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M (1997). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol. 42 (6): 847–56. doi:10.1002/ana.410420605. PMID 9403476.
• Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS (1998). "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis". Structure. 6 (8): 983–91. doi:10.1016/S0969-2126(98)00100-2. PMID 9739089.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Koyano S, Ito M, Takamatsu N, Shiba T, Yamamoto K, Yoshioka K (1999). "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Lett. 457 (3): 385–8. doi:10.1016/S0014-5793(99)01084-4. PMID 10471813.
• Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
• Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
• Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry. 39 (11): 3141–8. doi:10.1021/bi992410. PMID 10715136.
• McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496): 1574–7. doi:10.1126/science.290.5496.1574. PMID 11090355.
• Pouysségur J (2000). "Signal transduction. An arresting start for MAPK". Science. 290 (5496): 1515–8. doi:10.1126/science.290.5496.1515. PMID 11185509.
• Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z (2001). "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation". Nat. Cell Biol. 3 (3): 325–30. doi:10.1038/35060131. PMID 11231586.

External links

• MAP Kinase Resource .
• Overview of all the structural information available in the PDB for UniProt: P53779 (Mitogen-activated protein kinase 10) at the PDBe-KB.