NUAK2

NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene.[5][6]

NUAK2
Identifiers
Aliases	NUAK2, SNARK, NUAK family kinase 2
External IDs	OMIM: 608131 MGI: 1921387 HomoloGene: 12539 GeneCards: NUAK2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,302,063 bp[1] End 205,321,760 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,316,126 bp[2] End 132,333,488 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • protein kinase activity • metal ion binding • kinase activity • transferase activity • protein serine/threonine kinase activity • ATP binding • magnesium ion binding Cellular component • cytoplasm • cell nucleus Biological process • phosphorylation • apoptotic process • actin cytoskeleton organization • negative regulation of apoptotic process • GO:0007243 intracellular signal transduction • protein phosphorylation • cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81788	74137
Ensembl	ENSG00000163545	ENSMUSG00000009772
UniProt	Q9H093	Q8BZN4
RefSeq (mRNA)	NM_030952	NM_001195025 NM_028778
RefSeq (protein)	NP_112214	NP_001181954 NP_083054
Location (UCSC)	Chr 1: 205.3 – 205.32 Mb	Chr 1: 132.32 – 132.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163545 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009772 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. "Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lefebvre DL, Bai Y, Shahmolky N, et al. (2001). "Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK". Biochem. J. 355 (Pt 2): 297–305. doi:10.1042/0264-6021:3550297. PMC 1221739. PMID 11284715.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family". Biochem. Biophys. Res. Commun. 311 (1): 156–61. doi:10.1016/j.bbrc.2003.09.184. PMID 14575707.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Legembre P, Schickel R, Barnhart BC, Peter ME (2004). "Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness". J. Biol. Chem. 279 (45): 46742–7. doi:10.1074/jbc.M404334200. PMID 15345718.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.