KSR2

The KSR2 gene (also called "The fat gene") is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene.[5] KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.[6]

KSR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y4I
Identifiers
Aliases	KSR2, kinase suppressor of ras 2
External IDs	OMIM: 610737 MGI: 3610315 HomoloGene: 45469 GeneCards: KSR2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.22-q24.23 Start 117,453,012 bp[1] End 117,968,990 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 117,414,000 bp[2] End 117,775,003 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein serine/threonine kinase activity • ATP binding • metal ion binding • kinase activity • protein kinase activity • signal transducer activity • GO:0001948 protein binding Cellular component • cytoplasm • membrane • cytosol • cell membrane Biological process • GO:0007243 intracellular signal transduction • phosphorylation • protein phosphorylation • Ras protein signal transduction • calcium-mediated signaling • positive regulation of MAPK cascade • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283455	333050
Ensembl	ENSG00000171435	ENSMUSG00000061578
UniProt	Q6VAB6	Q3UVC0
RefSeq (mRNA)	NM_173598	NM_001034873 NM_001114545 NM_001312914
RefSeq (protein)	NP_775869	NP_001299843
Location (UCSC)	Chr 12: 117.45 – 117.97 Mb	Chr 5: 117.41 – 117.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000171435 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061578 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "KSR2". Entrez Gene.
6. Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, et al. (November 2013). "KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation". Cell. 155 (4): 765–77. doi:10.1016/j.cell.2013.09.058. PMC 3898740. PMID 24209692.