MARK3

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.[5][6]

MARK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QNJ, 3FE3
Identifiers
Aliases	MARK3, CTAK1, KP78, PAR1A, Par-1a, microtubule affinity regulating kinase 3, VIPB
External IDs	OMIM: 602678 MGI: 1341865 HomoloGene: 55653 GeneCards: MARK3
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.32-q32.33 Start 103,385,392 bp[1] End 103,503,831 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 111,574,523 bp[2] End 111,656,221 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948 protein binding • ATP binding • protein serine/threonine kinase activity • tau protein binding • tau-protein kinase activity Cellular component • cytosol • membrane • extracellular exosome • cell membrane • cytoplasm • dendrite • cell projection Biological process • phosphorylation • MAPK cascade • protein phosphorylation • microtubule cytoskeleton organization • establishment of cell polarity • negative regulation of hippo signaling • peptidyl-serine phosphorylation • positive regulation of protein binding • GO:0007243 intracellular signal transduction • peptidyl-serine autophosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4140	17169
Ensembl	ENSG00000075413	ENSMUSG00000007411
UniProt	P27448	Q03141
RefSeq (mRNA)	NM_001128918 NM_001128919 NM_001128920 NM_001128921 NM_002376	NM_021516 NM_022801 NM_001370744 NM_001370745
RefSeq (protein)	NP_001122390 NP_001122391 NP_001122392 NP_001122393 NP_002367	NP_067491 NP_073712 NP_001357673 NP_001357674
Location (UCSC)	Chr 14: 103.39 – 103.5 Mb	Chr 12: 111.57 – 111.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MARK3 has been shown to interact with Stratifin.[7][8]

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000075413 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007411 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ono T, Kawabe T, Sonta S, Okamoto T (April 1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 101–2. doi:10.1159/000134692. PMID 9533022.
6. "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
8. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
9. https://www.unige.ch/communication/communiques/2018/cdp180723/

Further reading

• Tassan JP, Le Goff X (2004). "An overview of the KIN1/PAR-1/MARK kinase family". Biol. Cell. 96 (3): 193–9. doi:10.1016/j.biolcel.2003.10.009. PMID 15182702.
• Meller N, Liu YC, Collins TL, Bonnefoy-Bérard N, Baier G, Isakov N, Altman A (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function". Mol. Cell. Biol. 16 (10): 5782–91. doi:10.1128/MCB.16.10.5782. PMC 231579. PMID 8816492.
• Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H (1998). "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding". Cell Growth Differ. 9 (3): 197–208. PMID 9543386.
• Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID 11433294.
• Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D (2003). "Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1". Oncogene. 22 (30): 4752–6. doi:10.1038/sj.onc.1206669. PMID 12879020.
• Müller J, Ritt DA, Copeland TD, Morrison DK (2003). "Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate". EMBO J. 22 (17): 4431–42. doi:10.1093/emboj/cdg426. PMC 202368. PMID 12941695.
• Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
• Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
• Bachmann M, Hennemann H, Xing PX, Hoffmann I, Möröy T (2005). "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint". J. Biol. Chem. 279 (46): 48319–28. doi:10.1074/jbc.M404440200. PMID 15319445.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR (2007). "Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation". J. Cell Sci. 119 (Pt 19): 4059–70. doi:10.1242/jcs.03097. PMID 16968750.
• Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R (2006). "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases" (PDF). Mol. Cell. Biol. 26 (19): 7086–102. doi:10.1128/MCB.00231-06. PMC 1592903. PMID 16980613.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.