GNG11

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene.[5][6]

GNG11
Identifiers
Aliases	GNG11, GNGT11, G protein subunit gamma 11
External IDs	OMIM: 604390 MGI: 1913316 HomoloGene: 3045 GeneCards: GNG11
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 93,921,735 bp[1] End 93,928,610 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 4,003,904 bp[2] End 4,008,445 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • GTPase activity • GO:0001948 protein binding • G-protein beta-subunit binding Cellular component • cell membrane • membrane • heterotrimeric G-protein complex • G-protein beta/gamma-subunit complex Biological process • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2791	66066
Ensembl	ENSG00000127920	ENSMUSG00000032766
UniProt	P61952	P61953
RefSeq (mRNA)	NM_004126	NM_025331
RefSeq (protein)	NP_004117	NP_079607
Location (UCSC)	Chr 7: 93.92 – 93.93 Mb	Chr 6: 4 – 4.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein.

As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000127920 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032766 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J Biol Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
6. "Entrez Gene: GNG11 guanine nucleotide binding protein (G protein), gamma 11".

Further reading

• Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Ruiz-Ballesteros E, Mollejo M, Rodriguez A, et al. (2005). "Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis". Blood. 106 (5): 1831–8. doi:10.1182/blood-2004-10-3898. PMID 15914563.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hossain MN, Sakemura R, Fujii M, Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence". Biochem. Biophys. Res. Commun. 351 (3): 645–50. doi:10.1016/j.bbrc.2006.10.112. PMID 17092487.