RPS6KA4

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[5][6][7]

RPS6KA4
Identifiers
Aliases	RPS6KA4, MSK2, RSK-B, S6K-alpha-4, ribosomal protein S6 kinase A4
External IDs	OMIM: 603606 MGI: 1930076 HomoloGene: 69288 GeneCards: RPS6KA4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,359,148 bp[1] End 64,372,215 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,829,085 bp[2] End 6,840,636 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • ribosomal protein S6 kinase activity • GO:0001948 protein binding • ATP binding • magnesium ion binding Cellular component • nucleoplasm • cell nucleus • cytoplasm • cytosol Biological process • GO:0007243 intracellular signal transduction • regulation of transcription, DNA-templated • phosphorylation • histone H3-S10 phosphorylation • positive regulation of histone acetylation • interleukin-1-mediated signaling pathway • protein phosphorylation • histone phosphorylation • positive regulation of CREB transcription factor activity • positive regulation of histone phosphorylation • positive regulation of NF-kappaB transcription factor activity • inflammatory response • negative regulation of cytokine production • positive regulation of transcription from RNA polymerase II promoter • histone H3-S28 phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8986	56613
Ensembl	ENSG00000162302	ENSMUSG00000024952
UniProt	O75676	Q9Z2B9
RefSeq (mRNA)	NM_001006944 NM_001300802 NM_003942 NM_001318361	NM_019924
RefSeq (protein)	NP_001006945 NP_001287731 NP_001305290 NP_003933	NP_064308
Location (UCSC)	Chr 11: 64.36 – 64.37 Mb	Chr 19: 6.83 – 6.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

Interactions

RPS6KA4 has been shown to interact with MAPK14.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000162302 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024952 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677.
6. Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
7. "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4".

Further reading

• Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–963. Bibcode:1996Sci...273..959X. doi:10.1126/science.273.5277.959. PMID 8688081.
• Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–32379. doi:10.1074/jbc.273.49.32377. PMID 9829964.
• Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor". J. Biol. Chem. 275 (31): 23549–23558. doi:10.1074/jbc.M002586200. PMID 10806207.
• Tomás-Zuber M, Mary JL, Lamour F, et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)". J. Biol. Chem. 276 (8): 5892–5899. doi:10.1074/jbc.M005822200. PMID 11035004.
• Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–6333. doi:10.1038/sj.onc.1204007. PMID 11175347.
• Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–5178. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.
• Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
• Soloaga A, Thomson S, Wiggin GR, et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. PMC 156769. PMID 12773393.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–547. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
• Gesser B, Johansen C, Rasmussen MK, et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect". J. Invest. Dermatol. 127 (9): 2129–2137. doi:10.1038/sj.jid.5700859. PMID 17495961.