MAST1

Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.[5]

MAST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M9X, 3PS4
Identifiers
Aliases	MAST1, SAST, SAST170, microtubule associated serine/threonine kinase 1, MCCCHCM
External IDs	OMIM: 612256 MGI: 1861901 HomoloGene: 10543 GeneCards: MAST1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,833,951 bp[1] End 12,874,952 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.32 cM Start 84,911,903 bp[2] End 84,937,359 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • magnesium ion binding • metal ion binding • kinase activity Cellular component • cytoplasm • cell membrane • intracellular • cytoskeleton • membrane Biological process • protein phosphorylation • GO:0007243 intracellular signal transduction • cytoskeleton organization • peptidyl-serine phosphorylation • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22983	56527
Ensembl	ENSG00000105613	ENSMUSG00000053693
UniProt	Q9Y2H9	Q9R1L5
RefSeq (mRNA)	NM_014975	NM_019945
RefSeq (protein)	NP_055790	NP_064329
Location (UCSC)	Chr 19: 12.83 – 12.87 Mb	Chr 8: 84.91 – 84.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000105613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053693 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MAST1 microtubule associated serine/threonine kinase 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Yano R, Yap CC, Yamazaki Y, et al. (2003). "Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions". Neuroscience. 117 (2): 373–81. doi:10.1016/S0306-4522(02)00785-6. PMID 12614677.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184.
• Lumeng C, Phelps S, Crawford GE, et al. (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.