PFTK1

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.[5][6][7]

CDK14
Identifiers
Aliases	CDK14, PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM: 610679 MGI: 894318 HomoloGene: 7888 GeneCards: CDK14
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 90,466,424 bp[1] End 91,210,590 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 2.61 cM Start 4,803,391 bp[2] End 5,420,312 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • cyclin binding Cellular component • membrane • cell membrane • cytoplasmic cyclin-dependent protein kinase holoenzyme complex • cell nucleus • cytoplasm • cytosol Biological process • phosphorylation • regulation of canonical Wnt signaling pathway • Wnt signaling pathway • cell division • protein phosphorylation • G2/M transition of mitotic cell cycle • cell cycle • regulation of cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5218	18647
Ensembl	ENSG00000058091	ENSMUSG00000028926
UniProt	O94921	O35495
RefSeq (mRNA)	NM_001287135 NM_001287136 NM_001287137 NM_012395	NM_011074 NM_001310448
RefSeq (protein)	NP_001274064 NP_001274065 NP_001274066 NP_036527	NP_001297377 NP_035204
Location (UCSC)	Chr 7: 90.47 – 91.21 Mb	Chr 5: 4.8 – 5.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PFTK1 has been shown to interact with SEPT8.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000058091 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028926 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329.
6. Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
7. "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
8. Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. China. 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 520–5. PMID 12098780.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
• Gao Y, Jiang M, Yang T, et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539–47. doi:10.1038/sj.cr.7310071. PMID 16775625.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Shu F, Lv S, Qin Y, et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. Bibcode:2007PNAS..104.9248S. doi:10.1073/pnas.0703327104. PMC 1890480. PMID 17517622.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.