Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[5][6][7]

SLC5A6
Identifiers
Aliases	SLC5A6, SMVT, solute carrier family 5 member 6
External IDs	OMIM: 604024 MGI: 2660847 HomoloGene: 23277 GeneCards: SLC5A6
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,199,587 bp[1] End 27,212,958 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,036,036 bp[2] End 31,048,924 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • symporter activity • sodium-dependent multivitamin transmembrane transporter activity • GO:0022891 transmembrane transporter activity Cellular component • vesicle membrane • integral component of membrane • brush border membrane • cell membrane • integral component of plasma membrane • membrane Biological process • ion transport • sodium ion transport • biotin transport • pantothenate transmembrane transport • transmembrane transport • biotin metabolic process • pantothenate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8884	330064
Ensembl	ENSG00000138074	ENSMUSG00000006641
UniProt	Q9Y289	Q5U4D8
RefSeq (mRNA)	NM_021095	NM_001177621 NM_001177622 NM_177870 NM_001360022
RefSeq (protein)	NP_066918	NP_001171092 NP_001171093 NP_808538 NP_001346951
Location (UCSC)	Chr 2: 27.2 – 27.21 Mb	Chr 5: 31.04 – 31.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It is a putative transporter for uptake of biotin and pantothenic acid at the blood-brain barrier.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000138074 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006641 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
6. Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
7. "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
8. Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

Further reading

• Prasad PD, Wang H, Huang W, et al. (1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Arch. Biochem. Biophys. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
• Zempleni J, Steven Stanley J, Mock DM (2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
• Dey S, Subramanian VS, Chatterjee NS, et al. (2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochim. Biophys. Acta. 1574 (2): 187–92. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Balamurugan K, Ortiz A, Said HM (2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (1): G73–7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Balamurugan K, Vaziri ND, Said HM (2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". Am. J. Physiol. Renal Physiol. 288 (4): F823–31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Luo S, Kansara VS, Zhu X, et al. (2006). "Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery". Mol. Pharm. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865.
• Reidling JC, Nabokina SM, Said HM (2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G275–81. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
• Reidling JC, Said HM (2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". Am. J. Physiol., Cell Physiol. 292 (4): C1305–12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.