Large neutral amino acids transporter small subunit 1

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, is a protein that in humans is encoded by the SLC7A5 gene.[5]

SLC7A5
Identifiers
Aliases	SLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1, solute carrier family 7 member 5
External IDs	OMIM: 600182 MGI: 1298205 HomoloGene: 55759 GeneCards: SLC7A5
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 87,830,023 bp[1] End 87,869,507 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 Start 121,881,150 bp[2] End 121,907,694 bp[2]
Gene ontology Molecular function • peptide antigen binding • L-amino acid transmembrane transporter activity • amino acid transmembrane transporter activity • neutral amino acid transmembrane transporter activity • antiporter activity • GO:0001948 protein binding • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • cell membrane • apical plasma membrane • extracellular exosome • integral component of plasma membrane • cytoplasm • cytosol Biological process • amino acid transmembrane transport • cell differentiation • cellular amino acid metabolic process • nervous system development • multicellular organism development • L-amino acid transport • neutral amino acid transport • leukocyte migration • amino acid transport • L-alpha-amino acid transmembrane transport • transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8140	20539
Ensembl	ENSG00000103257	ENSMUSG00000040010
UniProt	Q01650	Q9Z127
RefSeq (mRNA)	NM_003486	NM_011404
RefSeq (protein)	NP_003477	NP_035534
Location (UCSC)	Chr 16: 87.83 – 87.87 Mb	Chr 8: 121.88 – 121.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Heterodimeric amino acid transporter

References

1. GRCh38: Ensembl release 89: ENSG00000103257 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040010 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

Further reading

• Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma". Lung Cancer. 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406.
• Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788.
• Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379.
• Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells". Brain Tumor Pathol. 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110.
• Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMID 18294274.
• Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359.
• Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 Suppl 1: 11P–16P. PMID 10629848.
• Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555.
• Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg Oncol. 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882.
• Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism". Neurogenetics. 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMC 2753863. PMID 19184136.
• Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724.
• Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells". Neurosurgery. 62 (2): 493–503, discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329.
• Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer". Br. J. Cancer. 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMC 2259171. PMID 18253116.
• Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMID 19018776.
• Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer". Histopathology. 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099.
• Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells". Oncol. Rep. 20 (4): 885–9. doi:10.3892/or_00000087. PMID 18813831.
• Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087.