Probable low affinity copper uptake protein 2

Probable low affinity copper uptake protein 2 is a protein that in humans is encoded by the SLC31A2 gene.[5][6]

SLC31A2
Identifiers
Aliases	SLC31A2, COPT2, CTR2, hCTR2, solute carrier family 31 member 2
External IDs	OMIM: 603088 MGI: 1333844 HomoloGene: 37536 GeneCards: SLC31A2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 113,150,976 bp[1] End 113,164,140 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 62,262,562 bp[2] End 62,298,411 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • copper ion transmembrane transporter activity Cellular component • integral component of membrane • recycling endosome • late endosome • integral component of plasma membrane • membrane • cell membrane Biological process • copper ion transport • ion transport • copper ion transmembrane transport • regulation of copper ion transmembrane transport • cellular copper ion homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1318	20530
Ensembl	ENSG00000136867	ENSMUSG00000066152
UniProt	O15432	Q9CPU9
RefSeq (mRNA)	NM_001860	NM_001290518 NM_025286
RefSeq (protein)	NP_001851	NP_001277447 NP_079562
Location (UCSC)	Chr 9: 113.15 – 113.16 Mb	Chr 4: 62.26 – 62.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000136867 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066152 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou B, Gitschier J (Aug 1997). "hCTR1: a human gene for copper uptake identified by complementation in yeast". Proc Natl Acad Sci U S A. 94 (14): 7481–6. doi:10.1073/pnas.94.14.7481. PMC 23847. PMID 9207117.
6. "Entrez Gene: SLC31A2 solute carrier family 31 (copper transporters), member 2".

Further reading

• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• van den Berghe PV, Folmer DE, Malingré HE, van Beurden E, Klomp AE, van de Sluis B, Merkx M, Berger R, Klomp LW (2007). "Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake". Biochem. J. 407 (1): 49–59. doi:10.1042/BJ20070705. PMC 2267400. PMID 17617060.