SLC2A7

Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene.[5][6]

SLC2A7
Identifiers
Aliases	SLC2A7, GLUT7, solute carrier family 2 member 7, GLUT-7, hGLUT7
External IDs	OMIM: 610371 MGI: 3650865 HomoloGene: 72470 GeneCards: SLC2A7
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 9,003,300 bp[1] End 9,026,345 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 Start 150,148,972 bp[2] End 150,168,482 bp[2]
Gene ontology Molecular function • transporter activity • GO:0022891 transmembrane transporter activity • sugar transmembrane transporter activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • carbohydrate transport • transmembrane transport • hexose transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	155184	435818
Ensembl	ENSG00000197241	ENSMUSG00000062064
UniProt	Q6PXP3	P0C6A1
RefSeq (mRNA)	NM_207420	NM_001085529 NM_001368869
RefSeq (protein)	NP_997303	NP_001078998 NP_001355798
Location (UCSC)	Chr 1: 9 – 9.03 Mb	Chr 4: 150.15 – 150.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion.[6] This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues.[7]

See also

• Glucose transporter

References

1. GRCh38: Ensembl release 89: ENSG00000197241 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062064 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 2 (facilitated glucose transporter)".
6. Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young JD, Chen XZ, Cheeseman CI (July 2004). "Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (1): G236–42. doi:10.1152/ajpgi.00396.2003. PMID 15033637.
7. Joost HG, Thorens B (2001). "The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)". Mol. Membr. Biol. 18 (4): 247–56. doi:10.1080/09687680110090456. PMID 11780753.

Further reading

• Manolescu A, Salas-Burgos AM, Fischbarg J, Cheeseman CI (2005). "Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7)". J. Biol. Chem. 280 (52): 42978–83. doi:10.1074/jbc.M508678200. PMID 16186102.