Brain mitochondrial carrier protein 1

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.[5][6]

SLC25A14
Identifiers
Aliases	SLC25A14, solute carrier family 25 (mitochondrial carrier, brain), member 14, BMCP1, UCP5, solute carrier family 25 member 14
External IDs	OMIM: 300242 MGI: 1330823 HomoloGene: 2937 GeneCards: SLC25A14
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.1 Start 130,339,888 bp[1] End 130,373,361 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A5|X 25.69 cM Start 48,623,413 bp[2] End 48,662,294 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0022891 transmembrane transporter activity • sulfate transmembrane transporter activity • thiosulfate transmembrane transporter activity • oxaloacetate transmembrane transporter activity • malate transmembrane transporter activity • succinate transmembrane transporter activity • antiporter activity Cellular component • membrane • mitochondrial envelope • integral component of membrane • mitochondrion • mitochondrial membranes • integral component of plasma membrane • mitochondrial inner membrane Biological process • aerobic respiration • mitochondrial transport • transmembrane transport • hydrogen ion transmembrane transport • sulfate transport • thiosulfate transport • oxaloacetate transport • phosphate ion transmembrane transport • succinate transmembrane transport • malate transmembrane transport • oxaloacetate(2-) transmembrane transport • sulfate transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9016	20523
Ensembl	ENSG00000102078	ENSMUSG00000031105
UniProt	O95258	Q9Z2B2
RefSeq (mRNA)	NM_001282195 NM_001282196 NM_001282197 NM_001282198 NM_003951 NM_022810	NM_001166450 NM_001290703 NM_001290704 NM_001290705 NM_011398 NM_001359136
RefSeq (protein)	NP_001269124 NP_001269125 NP_001269126 NP_001269127	NP_001159922 NP_001277632 NP_001277633 NP_001277634 NP_035528 NP_001346065
Location (UCSC)	Chr X: 130.34 – 130.37 Mb	Chr X: 48.62 – 48.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.[6]

See also

• Solute carrier family
• Uncoupling protein

References

1. GRCh38: Ensembl release 89: ENSG00000102078 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031105 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, Gregoire F, Easlick J, Raimbault S, Levi-Meyrueis C, Miroux B, Collins S, Seldin M, Richard D, Warden C, Bouillaud F, Ricquier D (Jan 1999). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". J Biol Chem. 273 (51): 34611–5. doi:10.1074/jbc.273.51.34611. PMID 9852133.
6. "Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14".

Further reading

• Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". Biochem. J. 345 (2): 161–79. doi:10.1042/0264-6021:3450161. PMC 1220743. PMID 10620491.
• Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343.
• Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation". FASEB J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID 10928996.
• Kim-Han JS, Reichert SA, Quick KL, Dugan LL (2001). "BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production". J. Neurochem. 79 (3): 658–68. doi:10.1046/j.1471-4159.2001.00604.x. PMID 11701769.
• Yang X, Pratley RE, Tokraks S, et al. (2002). "UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates" (PDF). Mol. Genet. Metab. 75 (4): 369–73. doi:10.1016/S1096-7192(02)00008-2. PMID 12051969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Ho PW, Chu AC, Kwok KH, et al. (2007). "Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity". J. Neurosci. Res. 84 (6): 1358–66. doi:10.1002/jnr.21034. PMID 16941493.
• Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID 17066476.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.