Nepadutant

Nepadutant (INN) (code name MEN-11420) is a glycosylated bicyclic cyclohexapeptide drug which acts as a highly selective NK2 receptor antagonist.[2][3][4] It was developed by the Menarini Group and investigated for the treatment of functional gastrointestinal disorders and asthma but was never marketed.[3][5][6]

Nepadutant
Clinical data
Routes of
administration		Injection[1][2]
ATC code
  • None
Pharmacokinetic data
Bioavailability<3% (oral)[1]
Elimination half-life44 minutes (IV)[1]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC45H60N10O14
Molar mass965.031 g·mol−1
3D model (JSmol)

See also

References
  1. Annual Reports in Medicinal Chemistry. Academic Press. 8 September 1999. pp. 56–. ISBN 978-0-08-058378-5.
  2. Peter Holzer (17 June 2004). Tachykinins. Springer. pp. 224–226. ISBN 978-3-540-20690-3.
  3. Vera Regitz-Zagrosek (2 October 2012). Sex and Gender Differences in Pharmacology. Springer Science & Business Media. pp. 489–. ISBN 978-3-642-30726-3.
  4. Royal Society of Chemistry (Great Britain) (January 2003). Amino Acids, Peptides and Proteins. Royal Society of Chemistry. ISBN 978-0-85404-242-5.
  5. Barbara Frank (29 June 2011). Women's Issues in Gastroenterology, An Issue of Gastroenterology Clinics. Elsevier Health Sciences. pp. 54–55. ISBN 1-4557-1220-5.
  6. Gabor Jancso (27 November 2008). Neurogenic Inflammation in Health and Disease. Elsevier. pp. 297–. ISBN 978-0-444-53229-9.



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