N-Desalkylflurazepam

N-Desalkylflurazepam (also known as norflurazepam) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam,[2] flutoprazepam,[3] fludiazepam,[4] midazolam,[5] flutazolam[6], quazepam,[7] and ethyl loflazepate.[8][9] It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes.[7] It has been sold as a designer drug from 2016 onward.[10]

N-Desalkylflurazepam
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10ClFN2O
Molar mass288.71 g·mol−1
3D model (JSmol)
Melting point205 to 206 °C (401 to 403 °F) [1]

Synonyms
gollark: It annoys me that Children of a Dead Earth is apparently very good, *and* on sale right now, but also not available for Linux so I can't use it.
gollark: `nano` when I have to use a terminal to edit things, because the only `vim` command I can remember is the one to exit.
gollark: I don't use that and so can't really say specifically, but for general code editing use Visual Studio Code is good.
gollark: It seems to be bright grayish blue here, no idea about temperature.
gollark: For some weird reason, at school we only did Cambridge Latin Course for one year and then Latin to GCSE, by John Taylor and some other person.

References
  1. SciFinder record for CAS#2886-65-9
  2. Riva R, de Anna M, Albani F, Baruzzi A (March 1981). "Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas-liquid chromatography with electron-capture detection". Journal of Chromatography. 222 (3): 491–5. doi:10.1016/S0378-4347(00)84153-5. PMID 7228960.
  3. Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E (1989). "Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects". European Journal of Drug Metabolism and Pharmacokinetics. 14 (4): 293–8. doi:10.1007/bf03190114. PMID 2633923.
  4. Descotes J, ed. (December 1996). Human Toxicology (1st ed.). Elsevier Science. p. 43.
  5. Vogt S, Kempf J, Buttler J, Auwärter V, Weinmann W (2013). "Desalkylflurazepam found in patients' samples after high-dose midazolam treatment". Drug Testing and Analysis. 5 (9–10): 745–7. doi:10.1002/dta.1484. PMID 23713025.
  6. Miyaguchi H, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT, Inoue H, Kishi T (February 2006). "A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry". Forensic Science International. 157 (1): 57–70. doi:10.1016/j.forsciint.2005.03.011. PMID 15869852.
  7. Nikaido AM, Ellinwood EH (1987). "Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance". Psychopharmacology. 92 (4): 459–64. doi:10.1007/bf00176478. PMID 2888152.
  8. Ba BB, Iliadis A, Cano JP (1989). "Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites". Annals of Biomedical Engineering. 17 (6): 633–46. doi:10.1007/bf02367467. PMID 2574017.
  9. Davi H, Guyonnet J, Necciari J, Cautreels W (July 1985). "Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: comparison with solvent extraction and thin-layer chromatography". Journal of Chromatography. 342 (1): 159–65. doi:10.1016/S0378-4347(00)84498-9. PMID 2864352.
  10. Manchester KR, Maskell PD, Waters L (March 2018). "a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances". Drug Testing and Analysis. 10 (8): 1258–1269. doi:10.1002/dta.2387. PMID 29582576.
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