Ro05-4082

Ro05-4082 (N-methylclonazepam, ID-690) is a benzodiazepine derivative developed in the 1970s. It has sedative and hypnotic properties, and has around the same potency as clonazepam itself.[1] but was never introduced into clinical use. It is a structural isomer of meclonazepam (3-methylclonazepam), and similarly has been sold as a designer drug, first being identified in Sweden in 2017.[2]

Ro05-4082

Identifiers
IUPAC name 5-(2-chlorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
CAS Number	5527-71-9
PubChem CID	528222
Chemical and physical data
Formula	C16H12ClN3O3
Molar mass	329.74 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3Cl
InChI InChI=1S/C16H12ClN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 Key:AZVBJJDUDXZLTM-UHFFFAOYSA-N

See also

• Clonazolam
• Cloniprazepam
• Flunitrazepam

References

1. Fukuda H, Kudo Y, Ono H, Togari A, Tanaka Y (January 1977). "[Pharmacological study on 5-(o-chlorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (ID-690), with special reference to the effects on motor systems]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 73 (1): 123–34. doi:10.1254/fpj.73.123. PMID 558942.
2. "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.