ML-154

ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.[2]

ML-154

Clinical data
ATC code	none
Identifiers
IUPAC name 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
CAS Number	1345964-89-7
PubChem CID	46930969
ChemSpider	26360842
Chemical and physical data
Formula	C29H26BrN2PS
Molar mass	545.48 g·mol^−1
3D model (JSmol)	Interactive image
SMILES [Br-].C1(=CC=CC=C1)[P](=S)(C2=C([N+](=C3C=CC=C[N]23)C\C=C\C4=CC=CC=C4)C)C5=CC=CC=C5
InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+; Key:CJAQCMBWGUOBIX-ZUQRMPMESA-M

See also

• Neuropeptide S receptor

References

1. Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, et al. (November 2013). "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry. 56 (22): 9045–56. doi:10.1021/jm400904m. PMC 4877059. PMID 24171469.
2. Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, et al. (June 2013). "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience. 33 (24): 10132–42. doi:10.1523/JNEUROSCI.4742-12.2013. PMID 23761908.