Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[3][4][5]

MCHR2
Identifiers
Aliases	MCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2
External IDs	OMIM: 606111 HomoloGene: 50004 GeneCards: MCHR2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.2 Start 99,918,519 bp[1] End 99,994,247 bp[1]
Gene ontology Molecular function • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • phospholipase C-activating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84539	n/a
Ensembl	ENSG00000152034	n/a
UniProt	Q969V1	n/a
RefSeq (mRNA)	NM_032503 NM_001040179	n/a
RefSeq (protein)	NP_001035269 NP_115892	n/a
Location (UCSC)	Chr 6: 99.92 – 99.99 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[6]

See also

• Melanin-concentrating hormone receptor

References

1. GRCh38: Ensembl release 89: ENSG00000152034 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".
4. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.
5. Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.
6. Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ (June 2010). "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. doi:10.1055/s-0030-1249019. PMID 20340065.

External links

• "Melanin-Concentrating Hormone Receptors: MCH₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. Bibcode:2001PNAS...98.7564S. doi:10.1073/pnas.121170598. PMC 34708. PMID 11404457.
• An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. Bibcode:2001PNAS...98.7576A. doi:10.1073/pnas.131200698. PMC 34710. PMID 11416225.
• Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838.
• Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.
• Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.
• Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.
• Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.
• Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations". Proteins. 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878.
• Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.