Galanin receptor 3

Galanin receptor 3 (GAL₃) is a G-protein coupled receptor encoded by the GALR3 gene.[5]

GALR3
Identifiers
Aliases	GALR3, Galanin receptor 3
External IDs	OMIM: 603692 MGI: 1329003 HomoloGene: 20798 GeneCards: GALR3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,823,382 bp[1] End 37,825,485 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.7 cM Start 79,041,885 bp[2] End 79,043,558 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • galanin receptor activity • G-protein coupled receptor activity • signal transducer activity • peptide hormone binding • G-protein coupled peptide receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • non-motile cilium • cilium Biological process • learning or memory • phospholipase C-activating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • feeding behavior • positive regulation of transcription from RNA polymerase II promoter • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • chemical synaptic transmission • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of adenylate cyclase activity • galanin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8484	14429
Ensembl	ENSG00000128310	ENSMUSG00000114755
UniProt	O60755	O88853
RefSeq (mRNA)	NM_003614	NM_015738
RefSeq (protein)	NP_003605	NP_056553
Location (UCSC)	Chr 22: 37.82 – 37.83 Mb	Chr 15: 79.04 – 79.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[5]

See also

• Galanin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000128310 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000114755 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GALR3 galanin receptor 3".

Further reading

• Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA (Sep 1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". The Journal of Biological Chemistry. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565.
• Kolakowski LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF (Dec 1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". Journal of Neurochemistry. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121.
• Iismaa TP, Fathi Z, Hort YJ, Iben LG, Dutton JL, Baker E, Sutherland GR, Shine J (Dec 1998). "Structural organization and chromosomal localization of three human galanin receptor genes". Annals of the New York Academy of Sciences. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159.
• Lapsys NM, Furler SM, Henderson NK, Dutton JL, Hort YJ, Eisman JA, Shine J, Iismaa TP (Aug 1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Molecular and Cellular Probes. 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Berger A, Tuechler C, Almer D, Kogner P, Ratschek M, Kerbl R, Iismaa TP, Jones N, Sperl W, Kofler B (Feb 2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology. 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941.
• Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA (Jul 2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior. 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.
• Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, Langel U (Dec 2010). "Determining receptor-ligand interaction of human galanin receptor type 3". Neurochemistry International. 57 (7): 804–11. doi:10.1016/j.neuint.2010.08.018. PMID 20817064.

External links

• "Galanin Receptors: GAL₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.