Alimemazine

Alimemazine (INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).[2] It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic.[3] In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.[4]

Alimemazine
Clinical data
Other namestrimeprazine (BAN UK), trimeprazine (USAN US)
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: C
    Routes of
    administration    		Oral
    ATC code
    Legal status
    Legal status
    • UK: POM (Prescription only)
    Pharmacokinetic data
    MetabolismHepatic
    Elimination half-life4.78 ± 0.59 hours[1]
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.001.434
    Chemical and physical data
    FormulaC18H22N2S
    Molar mass298.45 g·mol−1
    3D model (JSmol)
      (verify)

    Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and prednisolone (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and antitussive in dogs.

    References
    1. Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology. 38 (3): 172–6. doi:10.1111/j.2042-7158.1986.tb04539.x. PMID 2871150.
    2. "PubChem CID 78032".
    3. "Drugbank:Trimeprazine".
    4. "Russian Register of Medicines: "Teraligen" film-coated tablets (alimemazine tartrate) Patient Information Leaflet (in Russian). Revised September 2013".


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