OR5AN1

Olfactory receptor 5AN1 is a protein that in humans is encoded by the OR5AN1 gene.[4]

OR5AN1
Identifiers
Aliases	OR5AN1, OR11-244, olfactory receptor family 5 subfamily AN member 1
External IDs	OMIM: 615702 MGI: 3031268 HomoloGene: 45029 GeneCards: OR5AN1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 59,358,895 bp[1] End 59,371,714 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • odorant binding • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway • detection of chemical stimulus involved in sensory perception Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390195	258680
Ensembl	ENSG00000176495	n/a
UniProt	Q8NGI8	n/a
RefSeq (mRNA)	NM_001004729	NM_146685
RefSeq (protein)	NP_001004729	n/a
Location (UCSC)	Chr 11: 59.36 – 59.37 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

• Civetone
• Muscone [5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176495 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".
5. Ahmed, L.; et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA. 115 (17): E3950–E3958. doi:10.1073/pnas.1713026115. PMC 5924878. PMID 29632183.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR5AN1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.