OR8I2

Olfactory receptor 8I2 is a protein that in humans is encoded by the OR8I2 gene.[4]

OR8I2
Identifiers
Aliases	OR8I2, OR11-170, olfactory receptor family 8 subfamily I member 2
External IDs	MGI: 3030938 HomoloGene: 64916 GeneCards: OR8I2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 56,093,277 bp[1] End 56,094,286 bp[1]
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • olfactory receptor activity • odorant binding Cellular component • integral component of membrane • cell membrane • membrane Biological process • response to stimulus • signal transduction • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	120586	258763
Ensembl	ENSG00000172154	n/a
UniProt	Q8N0Y5	A2AVB5
RefSeq (mRNA)	NM_001003750	NM_146767
RefSeq (protein)	NP_001003750	NP_666978
Location (UCSC)	Chr 11: 56.09 – 56.09 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000172154 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OR8I2 olfactory receptor, family 8, subfamily I, member 2".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR8I2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.