OR7A5

Olfactory receptor 7A5 is a protein that in humans is encoded by the OR7A5 gene.[5]

OR7A5
Identifiers
Aliases	OR7A5, HTPCR2, olfactory receptor family 7 subfamily A member 5
External IDs	MGI: 1333808 HomoloGene: 133620 GeneCards: OR7A5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,824,251 bp[1] End 14,835,285 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,028,741 bp[2] End 79,036,274 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26659	18357
Ensembl	ENSG00000188269	ENSMUSG00000060205
UniProt	Q15622	Q8VGU7
RefSeq (mRNA)	NM_017506 NM_001370480 NM_001370481 NM_001370482 NM_001370483	NM_147041
RefSeq (protein)	NP_059976 NP_001357409 NP_001357410 NP_001357411 NP_001357412	NP_667252
Location (UCSC)	Chr 19: 14.82 – 14.84 Mb	Chr 10: 79.03 – 79.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000188269 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060205 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR7A5 olfactory receptor, family 7, subfamily A, member 5".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. doi:10.1038/nature02399. PMID 15057824.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (1997). "Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome". Biochem. Biophys. Res. Commun. 237 (2): 283–287. doi:10.1006/bbrc.1997.7043. PMID 9268701.
• Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–246. doi:10.1006/geno.1996.4490. PMID 9119360.
• Parmentier M, Libert F, Schurmans S, et al. (1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–455. doi:10.1038/355453a0. PMID 1370859.

External links

• OR7A5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.