OR1D2

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.[4][5][6]

OR1D2
Identifiers
Aliases	OR1D2, OLFR1, OR17-4, olfactory receptor family 1 subfamily D member 2
External IDs	OMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 3,088,484 bp[1] End 3,104,422 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity • identical protein binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • chemotaxis • sensory perception of smell • signal transduction • single fertilization • response to stimulus • detection of chemical stimulus involved in sensory perception of smell • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4991	258153
Ensembl	ENSG00000184166	n/a
UniProt	P34982	Q7TRW7
RefSeq (mRNA)	NM_002548	NM_001011851
RefSeq (protein)	NP_002539	NP_001011851
Location (UCSC)	Chr 17: 3.09 – 3.1 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Expression

As well as bring expressed in the olfactory epithelium of the human nose, OR1D2 is special in that it is also expressed in human spermatozoa, where it is involved in sperm chemotaxis.[7]

Ligands

Bourgeonal is a reported ligand for OR1D2 that affects sperm chemotaxis.[7]

Ligands include:[7]

• Bourgeonal
• Canthoxal
• Cyclamal
• Floralazone
• Lilial
• Phenylacetaldehyde
• 3-phenylbutyraldehyde
• 3-phenylpropionaldehyde
• 4-phenylbutyraldehyde
• (p-tert-butylphenoxy)acetaldehyde

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000184166 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
5. Buck L, Axel R (May 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell. 65 (1): 175–87. doi:10.1016/0092-8674(91)90418-X. PMID 1840504.
6. "Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2".
7. Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (March 2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. doi:10.1126/science.1080376. PMID 12663925.

Further reading

• Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J (1992). "Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences". Brain Res. Mol. Brain Res. 13 (1–2): 159–63. doi:10.1016/0169-328X(92)90057-I. PMID 1315913.
• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
• Schurmans S, Muscatelli F, Miot F, et al. (1993). "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism". Cytogenet. Cell Genet. 63 (3): 200–4. doi:10.1159/000133534. PMID 8097991.
• Nekrasova E, Sosinskaya A, Natochin M, et al. (1996). "Overexpression, solubilization and purification of rat and human olfactory receptors". Eur. J. Biochem. 238 (1): 28–37. doi:10.1111/j.1432-1033.1996.0028q.x. PMID 8665947.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Spehr M, Gisselmann G, Poplawski A, et al. (2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. doi:10.1126/science.1080376. PMID 12663925.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR1D2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.