OR11H4

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene.[5]

OR11H4
Identifiers
Aliases	OR11H4, OR14-36, olfactory receptor family 11 subfamily H member 4
External IDs	MGI: 3030583 HomoloGene: 10652 GeneCards: OR11H4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,239,286 bp[1] End 20,244,349 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 50,736,171 bp[2] End 50,745,094 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • neurotransmitter receptor activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • dendrite Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • signal transduction • response to stimulus • G-protein coupled serotonin receptor signaling pathway • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390442	56858
Ensembl	ENSG00000176198	ENSMUSG00000059069
UniProt	Q8NGC9	E9Q438
RefSeq (mRNA)	NM_001004479	NM_020288
RefSeq (protein)	NP_001004479	NP_064684
Location (UCSC)	Chr 14: 20.24 – 20.24 Mb	Chr 14: 50.74 – 50.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

• Isovaleric acid[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059069 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR11H4 olfactory receptor, family 11, subfamily H, member 4".
6. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLoS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR11H4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.