IL17RB

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[5][6][7]

IL17RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDsOMIM: 605458 MGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.1Start53,846,568 bp[1]
End53,865,794 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55540

50905

Ensembl

ENSG00000056736

ENSMUSG00000015966

UniProt

Q9NRM6

Q9JIP3

RefSeq (mRNA)

NM_018725
NM_172234

NM_019583

RefSeq (protein)

NP_061195

NP_062529

Location (UCSC)Chr 3: 53.85 – 53.87 MbChr 14: 30 – 30.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000056736 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015966 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
  6. Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801.
  7. "Entrez Gene: IL17RB interleukin 17 receptor B".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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