IL17RB

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[5][6][7]

IL17RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VBC
Identifiers
Aliases	IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	OMIM: 605458 MGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 53,846,568 bp[1] End 53,865,794 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 18.39 cM Start 29,996,135 bp[2] End 30,008,896 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • interleukin-17 receptor activity Cellular component • cytoplasm • integral component of membrane • extracellular region • cell surface • integral component of plasma membrane • membrane • cell membrane Biological process • positive regulation of interleukin-5 secretion • defense response • positive regulation of inflammatory response • positive regulation of interleukin-13 secretion • regulation of cell growth • interleukin-17-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55540	50905
Ensembl	ENSG00000056736	ENSMUSG00000015966
UniProt	Q9NRM6	Q9JIP3
RefSeq (mRNA)	NM_018725 NM_172234	NM_019583
RefSeq (protein)	NP_061195	NP_062529
Location (UCSC)	Chr 3: 53.85 – 53.87 Mb	Chr 14: 30 – 30.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[7]

See also

• Interleukin-17 receptor

References

1. GRCh38: Ensembl release 89: ENSG00000056736 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015966 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
6. Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801.
7. "Entrez Gene: IL17RB interleukin 17 receptor B".

Further reading

• Schwandner R, Yamaguchi K, Cao Z (2000). "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction". J. Exp. Med. 191 (7): 1233–40. doi:10.1084/jem.191.7.1233. PMC 2193168. PMID 10748240.
• Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J. Biol. Chem. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy". Clin. Cancer Res. 12 (7 Pt 1): 1954–5. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
• Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen". Clin. Cancer Res. 12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019.
• Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer". J. Clin. Oncol. 24 (28): 4611–9. doi:10.1200/JCO.2006.06.6944. PMID 17008703.

External links

• IL17RB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.