Interleukin-28 receptor
Interleukin-28 receptor is a type II cytokine receptor found in skin cells. It binds interleukin-28 A and B as well as interleukin 29.[1] It consists of an α and shares a common β subunit with the interleukin-10 receptor.[2][3] Binding to the interleukin-28 receptor is important for fighting infection.[4]
| interleukin 28 receptor, alpha (interferon, lambda receptor) | |
|---|---|
| Identifiers | |
| Symbol | IL28RA |
| Alt. symbols | CRF2/12, IFNLR, IL-28R1 |
| NCBI gene | 163702 |
| HGNC | 18584 |
| OMIM | 607404 |
| RefSeq | NM_170743 |
| UniProt | Q8IU57 |
| Other data | |
| Locus | Chr. 1 p36.11 |
| interleukin 10 receptor, beta | |
|---|---|
| Identifiers | |
| Symbol | IL10RB |
| Alt. symbols | CRFB4, D21S58, D21S66 |
| NCBI gene | 3588 |
| HGNC | 5965 |
| OMIM | 123889 |
| RefSeq | NM_000628 |
| UniProt | Q08334 |
| Other data | |
| Locus | Chr. 21 q22.1-22.2 |
Structure
The interleukin-28 receptor is a complex made up of two protein chains; the interleukin-28 receptor alpha chain and the beta chain from another interleukin receptor (IL-10).[5]
Location
The Interleukin-28 receptor is found in skin cells, specifically keratinocytes and melanocytes found in the epidermis. It binds to the cytokine interleukin-28 that is produced by immune cells, specifically regulatory T cells and maturing dendritic cells, and other skin cells that have been virally infected.[4]
Function
When the cytokine Interleukin-28 binds to the interleukin-28 receptor it causes several cellular responses that aid the skin cells in fighting infection. In binding to the receptor interleukin-28 cell growth is inhibited and the cell begins to produce cellular receptors that can sense infection as well as proteins to fight a viral infection. The interleukin-28 receptor, once a ligand is bound will activate a signaling pathway that caused in increase in MHC class 1 production.[4]
References
- "IFNLR1 interferon lambda receptor 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-03-11.
- Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, et al. (January 2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nature Immunology. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210.
- Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, et al. (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nature Immunology. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119.
- Wolk K, Witte K, Sabat R (August 2010). "Interleukin-28 and interleukin-29: novel regulators of skin biology". Journal of Interferon & Cytokine Research. 30 (8): 617–28. doi:10.1089/jir.2010.0064. PMID 20712456.
- "Figure 1—figure supplement 2. Pfam genome neighborhood network (GNN)". dx.doi.org. Retrieved 2020-03-11.
External links
- Receptors,+Interleukin-28 at the US National Library of Medicine Medical Subject Headings (MeSH)