Interleukin-1 receptor

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]

See also: Interleukin-1 receptor family
interleukin 1 receptor, type I
Identifiers
SymbolIL1R1
Alt. symbolsIL1R, IL1RA
NCBI gene3554
HGNC5993
OMIM147810
RefSeqNM_000877
UniProtP14778
Other data
LocusChr. 2 q12
interleukin 1 receptor, type II
Identifiers
SymbolIL1R2
Alt. symbolsIL1RB
NCBI gene7850
HGNC5994
OMIM147811
RefSeqNM_173343
UniProtP27930
Other data
LocusChr. 2 q12
interleukin 1 receptor accessory protein
Identifiers
SymbolIL1RAP
Alt. symbolsIL-1RAcP, IL1R3, C3orf13
NCBI gene3556
HGNC5995
OMIM602626
RefSeqNM_134470
UniProtQ9NPH3
Other data
LocusChr. 3 q28

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]

References
  1. Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161.
  2. Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
  3. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.


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