IL36A

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene.[5][6]

IL36A
Identifiers
Aliases	IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, interleukin 36, alpha, interleukin 36 alpha
External IDs	OMIM: 605509 MGI: 1859324 HomoloGene: 8688 GeneCards: IL36A
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,005,459 bp[1] End 113,008,044 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.26 cM Start 24,215,418 bp[2] End 24,225,702 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-1 receptor binding • cytokine activity Cellular component • extracellular region • extracellular Biological process • positive regulation of interleukin-6 production • innate immune system • positive regulation of cytokine production • immune system process • inflammatory response • immune response • regulation of receptor activity • cytokine-mediated signaling pathway • neutrophil chemotaxis • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of JNK cascade • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27179	54448
Ensembl	ENSG00000136694	ENSMUSG00000026984
UniProt	Q9UHA7	Q9JLA2
RefSeq (mRNA)	NM_014440	NM_019450
RefSeq (protein)	NP_055255	NP_062323
Location (UCSC)	Chr 2: 113.01 – 113.01 Mb	Chr 2: 24.22 – 24.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136694 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026984 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
6. "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

Further reading

• Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
• Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
• Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
• Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.
• Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
• Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.
• Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
• Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
• Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.
• Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
• Garnero P, Borel O, Sornay-Rendu E, et al. (2003). "Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study". Bone. 31 (1): 43–50. doi:10.1016/S8756-3282(02)00810-4. PMID 12110411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
• Blumberg H, Dinh H, Trueblood ES, et al. (2007). "Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation". J. Exp. Med. 204 (11): 2603–14. doi:10.1084/jem.20070157. PMC 2118475. PMID 17908936.