CCBP2

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[5][6][7]

ACKR2
Identifiers
Aliases	ACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDs	OMIM: 602648 MGI: 1891697 HomoloGene: 992 GeneCards: ACKR2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 42,804,752 bp[1] End 42,887,974 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 121,898,355 bp[2] End 121,911,074 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • chemokine receptor activity • C-C chemokine binding • G-protein coupled receptor activity • scavenger receptor activity • C-C chemokine receptor activity • chemokine binding Cellular component • integral component of membrane • early endosome • recycling endosome • membrane • actin filament • endosome • cell membrane • integral component of plasma membrane • nucleoplasm • cytosol • nuclear membrane • intracellular membrane-bounded organelle • external side of plasma membrane Biological process • signal transduction • multicellular organism development • inflammatory response • immune response • chemokine-mediated signaling pathway • G-protein coupled receptor signaling pathway • chemotaxis • receptor-mediated endocytosis • positive regulation of cytosolic calcium ion concentration • calcium-mediated signaling • cell chemotaxis • vesicle-mediated transport • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1238	59289
Ensembl	ENSG00000144648	ENSMUSG00000044534
UniProt	O00590	O08707
RefSeq (mRNA)	NM_001296	NM_001276719 NM_021609
RefSeq (protein)	NP_001287	NP_001263648 NP_067622
Location (UCSC)	Chr 3: 42.8 – 42.89 Mb	Chr 9: 121.9 – 121.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144648 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044534 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
6. Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
7. "Entrez Gene: CCBP2 chemokine binding protein 2".

Further reading

• Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ (1997). "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5". J. Biol. Chem. 272 (19): 12495–504. doi:10.1074/jbc.272.19.12495. PMID 9139699.
• Nibbs RJ, Yang J, Landau NR, et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity". J. Biol. Chem. 274 (25): 17478–83. doi:10.1074/jbc.274.25.17478. PMID 10364178.
• Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689.
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
• Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
• Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
• Nibbs RJ, Kriehuber E, Ponath PD, et al. (2001). "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors". Am. J. Pathol. 158 (3): 867–77. doi:10.1016/s0002-9440(10)64035-7. PMC 1850343. PMID 11238036.
• Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.
• Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking". Blood. 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fra AM, Locati M, Otero K, et al. (2003). "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6". J. Immunol. 170 (5): 2279–82. doi:10.4049/jimmunol.170.5.2279. PMID 12594248.
• Kunkel EJ, Kim CH, Lazarus NH, et al. (2003). "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells". J. Clin. Invest. 111 (7): 1001–10. doi:10.1172/JCI17244. PMC 152588. PMID 12671049.
• Galliera E, Jala VR, Trent JO, et al. (2004). "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6". J. Biol. Chem. 279 (24): 25590–7. doi:10.1074/jbc.M400363200. PMID 15084596.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Neil SJ, Aasa-Chapman MM, Clapham PR, et al. (2005). "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes". J. Virol. 79 (15): 9618–24. doi:10.1128/JVI.79.15.9618-9624.2005. PMC 1181543. PMID 16014924.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• Human ACKR2 genome location and ACKR2 gene details page in the UCSC Genome Browser.
• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
• Human CCR9 genome location and CCR9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.