Leukotriene receptor

The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:

• Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
  • BLT₁ (Leukotriene B₄ receptor 1) – LTB4R
  • BLT₂ (Leukotriene B₄ receptor 2) – LTB4R2
• Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
  • CysLT₁ (Cysteinyl leukotriene receptor 1) – CYSLTR1
  • CysLT₂ (Cysteinyl leukotriene receptor 2) – CYSLTR2

The recently elucidated CysLT_E, represented by GPR99/OXGR1, may constitute a third CysLTR.[1]

See also

• Eicosanoid receptor
• Oxoeicosanoid receptor
• Prostaglandin receptor
• Thromboxane receptor

References

1. Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.

External links

• IUPHAR GPCR Database – Leukotriene receptors
• Leukotriene+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)