Fenleuton

Fenleuton (trade name Lofrin) is a drug that acts as a 5-lipoxygenase inhibitor and inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. It has been studied for potential use in veterinary medicine to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) in horses.[2]

Fenleuton

Clinical data
Trade names	Lofrin
ATC code	none
Identifiers
IUPAC name 1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea
CAS Number	141579-54-6
ChemSpider	65045
UNII	LG64454O6I
KEGG	D04151
Chemical and physical data
Formula	C17H15FN2O3
Molar mass	314.316 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(C#Cc1cccc(c1)Oc2ccc(cc2)F)N(C(=O)N)O
InChI InChI=InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21) Key:MWXPQCKCKPYBDR-UHFFFAOYSA-N[1]

References

1. "1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015.
2. Marr KA, Lees P, Page CP, Cunningham FM (1998). "Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease". J Vet Pharmacol Ther. 21 (3): 241–246. doi:10.1046/j.1365-2885.1998.00127.x. PMID 9673966.