FFAR2-FFAR3 receptor heteromer
The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.
| free fatty acid receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | FFAR2 |
| Alt. symbols | GPR43, FFA2R |
| NCBI gene | 2867 |
| HGNC | 4501 |
| OMIM | 603823 |
| RefSeq | NM_005306 |
| UniProt | O15552 |
| Other data | |
| Locus | Chr. 19 q13.1 |
| free fatty acid receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | FFAR3 |
| Alt. symbols | GPR41, FFA3R |
| NCBI gene | 2865 |
| HGNC | 4499 |
| OMIM | 603821 |
| RefSeq | NM_005304 |
| UniProt | O14843 |
| Other data | |
| Locus | Chr. 19 q13.1 |
Signal transduction
The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular calcium release and Arrestin beta 2 recruitment. The heteromer also lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases.[1]
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References
- Ang Z, Xiong D, Wu M, Ding JL (January 2018). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal. 32 (1): 289–303. doi:10.1096/fj.201700252RR. PMC 5731126. PMID 28883043.
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