Leukotriene B₄ receptor 1

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.[5][6][7]

LTB4R
Identifiers
Aliases	LTB4R, BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7, leukotriene B4 receptor
External IDs	OMIM: 601531 MGI: 1309472 HomoloGene: 22477 GeneCards: LTB4R
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,311,450 bp[1] End 24,318,036 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,765,962 bp[2] End 55,768,494 bp[2]
Gene ontology Molecular function • nucleotide binding • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • leukotriene receptor activity • signal transducer activity • leukotriene B4 receptor activity • galanin receptor activity Cellular component • integral component of membrane • membrane raft • cell membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • leukotriene signaling pathway • muscle contraction • neuropeptide signaling pathway • immune response • signal transduction • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1241	16995
Ensembl	ENSG00000213903 ENSG00000285456	ENSMUSG00000046908
UniProt	Q15722	O88855
RefSeq (mRNA)	NM_181657 NM_001143919	NM_008519
RefSeq (protein)	NP_001137391 NP_858043	NP_032545
Location (UCSC)	Chr 14: 24.31 – 24.32 Mb	Chr 14: 55.77 – 55.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Eicosanoid receptor
• Etalocib, an antagonist at the leukotriene B4 receptor

References

1. ENSG00000285456 GRCh38: Ensembl release 89: ENSG00000213903, ENSG00000285456 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046908 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics. 37 (2): 187–94. doi:10.1006/geno.1996.0541. PMID 8921391.
6. Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363–7. doi:10.1074/jbc.271.31.18363. PMID 8702478.
7. "Entrez Gene: LTB4R leukotriene B4 receptor".

Further reading

• Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family". J. Leukoc. Biol. 59 (1): 18–23. doi:10.1002/jlb.59.1.18. PMID 8558062.
• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.
• Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation". Allergology International. 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620–4. doi:10.1038/42506. PMID 9177352.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits". Biochem. J. 335 (1): 15–8. doi:10.1042/bj3350015. PMC 1219746. PMID 9742207.
• Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
• Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230.
• Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival". J. Immunol. 168 (7): 3570–6. doi:10.4049/jimmunol.168.7.3570. PMID 11907121.
• Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128.
• Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue". Am. J. Pathol. 161 (2): 421–8. doi:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367.
• Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116.
• Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor". Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 507: 357–61. doi:10.1007/978-1-4615-0193-0_55. ISBN 978-1-4613-4960-0. PMID 12664610.

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• LTB4R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Receptors,+Leukotriene+B4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.