S1PR2

Sphingosine-1-phosphate receptor 2 also known as S1PR2 or S1P₂ is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[5]

S1PR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZTI
Identifiers
Aliases	S1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDs	OMIM: 605111 MGI: 99569 HomoloGene: 3118 GeneCards: S1PR2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,221,433 bp[1] End 10,231,331 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.68 cM Start 20,962,361 bp[2] End 20,976,781 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • lipid binding • G-protein coupled receptor binding • G-protein coupled receptor activity • integrin binding • GO:0001948 protein binding • sphingosine-1-phosphate receptor activity Cellular component • membrane • integral component of membrane • cell membrane Biological process • activation of MAPK activity • actin cytoskeleton reorganization • positive regulation of establishment of endothelial barrier • positive regulation of cell proliferation • G-protein coupled receptor signaling pathway • filopodium assembly • signal transduction • sphingosine-1-phosphate signaling pathway • positive regulation of peptidyl-threonine phosphorylation • negative regulation of excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9294	14739
Ensembl	ENSG00000267534	ENSMUSG00000043895
UniProt	O95136	P52592
RefSeq (mRNA)	NM_004230	NM_010333
RefSeq (protein)	NP_004221	NP_034463
Location (UCSC)	Chr 19: 10.22 – 10.23 Mb	Chr 9: 20.96 – 20.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. [6] S1PR2 is expressed on neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system [7] [8]

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000267534 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043895 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2".
6. Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME, Schiavo G (14 January 2014). "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity". PLOS Biology. 12 (1): e1001763. doi:10.1371/journal.pbio.1001763. PMC 3891622. PMID 24453941.
7. Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME (9 July 2019). "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke". Proceedings of the National Academy of Sciences. 116 (28): 14270–14279. doi:10.1073/pnas.1905309116. PMC 6628809. PMID 31235580.
8. Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences. 42 (9): 644–656. doi:10.1016/j.tins.2019.05.006. PMID 31285047.

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
• MacLennan AJ, Browe CS, Gaskin AA, et al. (1994). "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development". Mol. Cell. Neurosci. 5 (3): 201–9. doi:10.1006/mcne.1994.1024. PMID 8087418.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
• Himmel HM, Meyer Zu Heringdorf D, Graf E, et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes". Mol. Pharmacol. 58 (2): 449–54. doi:10.1124/mol.58.2.449. PMID 10908314.
• Hla T (April 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1–4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
• Mazurais D, Robert P, Gout B, et al. (2002). "Cell type-specific localization of human cardiac S1P receptors". J. Histochem. Cytochem. 50 (5): 661–70. doi:10.1177/002215540205000507. PMID 11967277.
• Osada M, Yatomi Y, Ohmori T, et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist". Biochem. Biophys. Res. Commun. 299 (3): 483–7. doi:10.1016/S0006-291X(02)02671-2. PMID 12445827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sanchez T, Thangada S, Wu MT, et al. (2005). "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312–7. Bibcode:2005PNAS..102.4312S. doi:10.1073/pnas.0409784102. PMC 555509. PMID 15764699.
• Sanchez T, Skoura A, Wu MT, et al. (2007). "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312–8. doi:10.1161/ATVBAHA.107.143735. PMID 17431187.

External links

• "Lysophospholipid Receptors: S₁P₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.