S1PR3

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.[5]

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM: 601965 MGI: 1339365 HomoloGene: 3829 GeneCards: S1PR3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.1 Start 88,990,863 bp[1] End 89,005,155 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,408,639 bp[2] End 51,422,797 bp[2]
Gene ontology Molecular function • signal transducer activity • lipid binding • integrin binding • sphingosine-1-phosphate receptor activity • G-protein coupled receptor activity • GO:0001948 protein binding Cellular component • integral component of membrane • integral component of plasma membrane • membrane • cell membrane Biological process • Notch signaling pathway • signal transduction • anatomical structure morphogenesis • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • negative regulation of establishment of endothelial barrier • positive regulation of cell proliferation • sphingosine-1-phosphate signaling pathway • regulation of interleukin-1 beta production • cytokine production • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1903	13610
Ensembl	ENSG00000213694	ENSMUSG00000067586
UniProt	Q99500	Q9Z0U9
RefSeq (mRNA)	NM_005226	NM_010101
RefSeq (protein)	NP_005217	NP_034231
Location (UCSC)	Chr 9: 88.99 – 89.01 Mb	Chr 13: 51.41 – 51.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.[5]

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000213694 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067586 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3".

Further reading

• Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 16–24. doi:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438.
• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
• Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing". Ann. N. Y. Acad. Sci. 905: 142–58. doi:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
• An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
• Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway". Blood. 93 (9): 2984–90. PMID 10216094.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.
• Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146.
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
• Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor". Arch. Biochem. Biophys. 375 (1): 69–77. doi:10.1006/abbi.1999.1589. PMID 10683250.
• Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250.
• Kimura T, Watanabe T, Sato K, et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3". Biochem. J. 348 (1): 71–6. doi:10.1042/0264-6021:3480071. PMC 1221037. PMID 10794715.

External links

• "Lysophospholipid Receptors: S₁P₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.