SNF1LK2

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.[5][6]

SIK2
Identifiers
Aliases	SIK2, LOH11CR1I, QIK, SNF1LK2, SIK-2, salt inducible kinase 2
External IDs	OMIM: 608973 MGI: 2445031 HomoloGene: 22875 GeneCards: SIK2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,602,449 bp[1] End 111,730,855 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 50,892,801 bp[2] End 51,009,073 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • magnesium ion binding • metal ion binding • kinase activity Cellular component • cytoplasm • cell nucleus • nucleotide-activated protein kinase complex Biological process • autophosphorylation • protein phosphorylation • GO:0007243 intracellular signal transduction • phosphorylation • regulation of insulin receptor signaling pathway • cellular response to hormone stimulus • negative regulation of TOR signaling • cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23235	235344
Ensembl	ENSG00000170145	ENSMUSG00000037112
UniProt	Q9H0K1	Q8CFH6
RefSeq (mRNA)	NM_015191	NM_178710
RefSeq (protein)	NP_056006	NP_848825
Location (UCSC)	Chr 11: 111.6 – 111.73 Mb	Chr 9: 50.89 – 51.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SNF1LK2 has been shown to interact with CRTC2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000170145 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology. 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
6. "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
7. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry. 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
• Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology. 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
• Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry / FEBS. 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.