PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.[5][6]

PIK3R4
Identifiers
Aliases	PIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDs	OMIM: 602610 MGI: 1922919 HomoloGene: 24678 GeneCards: PIK3R4
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 130,678,934 bp[1] End 130,746,829 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 56.79 cM Start 105,642,978 bp[2] End 105,687,657 bp[2]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • 1-phosphatidylinositol-3-kinase activity Cellular component • cytosol • endosome • late endosome • phagocytic vesicle membrane • membrane • phosphatidylinositol 3-kinase complex, class III • nuclear pore • autophagosome • phosphatidylinositol 3-kinase complex, class III, type I • GO:0035085 axoneme • nucleus-vacuole junction • cytoplasmic vesicle • phosphatidylinositol 3-kinase complex, class III, type II • microtubule cytoskeleton • intracellular membrane-bounded organelle Biological process • cellular response to glucose starvation • regulation of cytokinesis • phosphorylation • late endosome to vacuole transport • autophagy of peroxisome • receptor catabolic process • positive regulation of phosphatidylinositol 3-kinase activity • protein phosphorylation • phosphatidylinositol biosynthetic process • protein targeting to vacuole • toll-like receptor 9 signaling pathway • macroautophagy • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30849	75669
Ensembl	ENSG00000196455	ENSMUSG00000032571
UniProt	Q99570	Q8VD65
RefSeq (mRNA)	NM_014602	NM_001081309 NM_029380
RefSeq (protein)	NP_055417	NP_001074778
Location (UCSC)	Chr 3: 130.68 – 130.75 Mb	Chr 9: 105.64 – 105.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000196455 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032571 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: phosphoinositide-3-kinase".
6. Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

Further reading

• Askham JM, Vaughan KT, Goodson HV, Morrison EE (2002). "Evidence That an Interaction between EB1 and p150Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.
• Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731.
• Matsunaga K, Saitoh T, Tabata K, et al. (2009). "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846. PMID 19270696.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takeshita F, Gursel I, Ishii KJ, et al. (2004). "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9". Semin. Immunol. 16 (1): 17–22. doi:10.1016/j.smim.2003.10.009. PMID 14751759.
• Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization". Mol. Biol. Cell. 14 (4): 1405–17. doi:10.1091/mbc.E02-03-0155. PMC 153110. PMID 12686597.
• Yan Y, Flinn RJ, Wu H, et al. (2009). "hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells". Biochem. J. 417 (3): 747–55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027.