Lipidology

Lipidology is the scientific study of lipids.

History

Compared to other biomedical fields, lipidology was originally less popular since the constant handling of oils, smears, and greases was unappealing and separation was difficult.[1] The field became more popular following the advent of chromatography which allowed lipids to be isolated and analyzed.[1] The field was further popularized following the cytologic application of the electron microscope which found that many metabolic pathways take place on the cell membrane, whose properties are strongly influenced by its lipid composition.[1]

Clinical lipidology

The Framingham Heart Study and other epidemiological studies have found a correlation between lipoproteins and cardiovascular disease.[2]

A class of lipids known as phospholipids help make up what is known as lipoproteins, and a type of lipoprotein is called high density lipoprotein (HDL).[3] A high concentration of high density lipoproteins-cholesterols (HDL-C) have what is known as a vasoprotective effect on the body, a finding that correlates with an enhanced cardiovascular effect.[4] There is also a correlation between those with diseases such as chronic kidney disease, coronary artery disease, or diabetes mellitus and the possibility of low vasoprotective effect from HDL.[5]

Therapeutic lipidology

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Lipidomics
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See also

References
  1. Kates, p. 275-276.
  2. Therapeutic lipidology, p. vii-viii
  3. Feingold, Kenneth R.; Grunfeld, Carl (2000), De Groot, Leslie J.; Chrousos, George; Dungan, Kathleen; Feingold, Kenneth R. (eds.), "Introduction to Lipids and Lipoproteins", Endotext, MDText.com, Inc., PMID 26247089, retrieved 2018-12-14
  4. Speer, Thimoteus; Meinitzer, Andreas; März, Winfried; Fliser, Danilo; Lüscher, Thomas F.; Landmesser, Ulf; von Eckardstein, Arnold; Laufs, Ulrich; Böger, Rainer H. (2017-05-21). "Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease". European Heart Journal. 38 (20): 1597–1607. doi:10.1093/eurheartj/ehx118. ISSN 0195-668X. PMID 28379378.
  5. Bell, David S.H. (October 1996). "Diabetes mellitus and coronary artery disease". Coronary Artery Disease. 7 (10): 715–722. doi:10.1097/00019501-199610000-00004. ISSN 0954-6928.
Books
  • Kates, Morris (1972), Techniques of lipidology; isolation, analysis and identification of lipids, Laboratory Techniques in Biochemistry and Molecular Biology, 3, Amsterdam, New York: North-Holland Pub. Co.American Elsevier, pp. 269–610, doi:10.1016/S0075-7535(08)70544-8, ISBN 978-0444103505
  • Therapeutic lipidology. Totowa, N.J.: Humana. 2007. ISBN 9781597455336.


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