Apolipoprotein C4

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.[5][6]

APOC4
Identifiers
Aliases	APOC4, APO-CIV, APOC-IV, apolipoprotein C4
External IDs	OMIM: 600745 MGI: 87878 HomoloGene: 1245 GeneCards: APOC4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,942,237 bp[1] End 44,945,496 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.94 cM Start 19,678,083 bp[2] End 19,681,479 bp[2]
Gene ontology Molecular function • lipid transporter activity Cellular component • high-density lipoprotein particle • extracellular region • very-low-density lipoprotein particle Biological process • lipid transport • positive regulation of sequestering of triglyceride • triglyceride homeostasis • lipid metabolism • very-low-density lipoprotein particle assembly • very-low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	346	11425
Ensembl	ENSG00000267467	ENSMUSG00000074336
UniProt	P55056	Q61268
RefSeq (mRNA)	NM_001646	NM_007385
RefSeq (protein)	NP_001637	NP_031411
Location (UCSC)	Chr 19: 44.94 – 44.95 Mb	Chr 7: 19.68 – 19.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. Apo C4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000267467 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074336 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: apolipoprotein C-IV".
6. Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics. 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID 8530039.

External links

• Human APOC4 genome location and APOC4 gene details page in the UCSC Genome Browser.

Further reading

• Kim E, Li K, Lieu C, et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis". J. Hepatol. 49 (5): 787–98. doi:10.1016/j.jhep.2008.06.029. PMC 2644636. PMID 18809223.
• Burkhardt R, Kenny EE, Lowe JK, et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. doi:10.1161/ATVBAHA.108.172288. PMC 2764366. PMID 18802019.
• Willer CJ, Sanna S, Jackson AU, et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMC 5206900. PMID 18193043.
• Mak PA, Laffitte BA, Desrumaux C, et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. doi:10.1074/jbc.M202993200. PMID 12032151.
• Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kathiresan S, Willer CJ, Peloso GM, et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMC 2881676. PMID 19060906.
• Mosbruger TL, Duggal P, Goedert JJ, et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
• Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular Medicine. 16 (9–10): 389–99. doi:10.2119/molmed.2010.00044. PMC 2935949. PMID 20498921.
• Marques-Vidal P, Bochud M, Paccaud F, et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis. 211 (2): 551–7. doi:10.1016/j.atherosclerosis.2010.04.001. PMID 20430392.
• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Drenos F, Talmud PJ, Casas JP, et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC 2685759. PMID 19336475.
• Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
• Mancone C, Amicone L, Fimia GM, et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics. 7 (1): 143–54. doi:10.1002/pmic.200600339. PMID 17154273.
• Lowe JK, Maller JB, Pe'er I, et al. (2009). Gibson G (ed.). "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLoS Genet. 5 (2): e1000365. doi:10.1371/journal.pgen.1000365. PMC 2628735. PMID 19197348.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis. 152 (1): 193–201. doi:10.1016/S0021-9150(99)00459-1. PMID 10996355.
• Klos KL, Sing CF, Boerwinkle E, et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. doi:10.1161/01.ATV.0000231523.19199.45. PMID 16763159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kotite L, Zhang LH, Yu Z, et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. doi:10.1194/jlr.M300087-JLR200. PMID 12700345.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.