EPHB6

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.[5]

EPHB6
Identifiers
Aliases	EPHB6, HEP, EPH receptor B6
External IDs	OMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 142,855,061 bp[1] End 142,871,094 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.1 Start 41,605,482 bp[2] End 41,620,509 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein kinase activity • GO:0001948 protein binding • ATP binding • ephrin receptor activity • signaling receptor activity • protein tyrosine kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity • transmembrane-ephrin receptor activity • transmembrane receptor protein tyrosine kinase activity Cellular component • integral component of membrane • extracellular region • cytosol • cell membrane • integral component of plasma membrane • membrane • cytoplasm • neuron projection • receptor complex Biological process • protein phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • ephrin receptor signaling pathway • peptidyl-tyrosine phosphorylation • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2051	13848
Ensembl	ENSG00000106123 ENSG00000275482	ENSMUSG00000029869
UniProt	O15197	O08644
RefSeq (mRNA)	NM_001280794 NM_001280795 NM_004445	NM_001146351 NM_007680
RefSeq (protein)	NP_001267723 NP_001267724 NP_004436	NP_001139823 NP_031706
Location (UCSC)	Chr 7: 142.86 – 142.87 Mb	Chr 6: 41.61 – 41.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[5]

References

1. ENSG00000275482 GRCh38: Ensembl release 89: ENSG00000106123, ENSG00000275482 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029869 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EPHB6 EPH receptor B6".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: Regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Matsuoka H, Iwata N, Ito M, et al. (1997). "Expression of a kinase-defective Eph-like receptor in the normal human brain". Biochem. Biophys. Res. Commun. 235 (3): 487–92. doi:10.1006/bbrc.1997.6812. PMID 9207182.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
• Munthe E, Rian E, Holien T, et al. (2000). "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6". FEBS Lett. 466 (1): 169–74. doi:10.1016/S0014-5793(99)01793-7. PMID 10648835.
• Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells". Growth Factors. 18 (1): 63–78. doi:10.3109/08977190009003234. PMID 10831073.
• Tang XX, Zhao H, Robinson ME, et al. (2000). "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. doi:10.1073/pnas.190123297. PMC 27127. PMID 10984508.
• Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells". J. Immunol. 167 (3): 1362–70. doi:10.4049/jimmunol.167.3.1362. PMID 11466354.