STYK1

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.[5][6]

STYK1
Identifiers
Aliases	STYK1, NOK, SuRTK106, serine/threonine/tyrosine kinase 1
External IDs	OMIM: 611433 MGI: 2141396 HomoloGene: 49545 GeneCards: STYK1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,618,923 bp[1] End 10,674,318 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 131,299,142 bp[2] End 131,353,597 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein tyrosine kinase activity • receptor binding • non-membrane spanning protein tyrosine kinase activity • GO:0001948 protein binding • ATP binding • kinase activity Cellular component • integral component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • membrane Biological process • peptidyl-tyrosine autophosphorylation • cell differentiation • protein phosphorylation • innate immune system • cell migration • regulation of cell proliferation • phosphorylation • chemotaxis • cell adhesion • epidermal growth factor receptor signaling pathway • regulation of mast cell degranulation • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55359	243659
Ensembl	ENSG00000060140	ENSMUSG00000032899
UniProt	Q6J9G0	Q6J9G1
RefSeq (mRNA)	NM_018423	NM_172891
RefSeq (protein)	NP_060893	NP_766479
Location (UCSC)	Chr 12: 10.62 – 10.67 Mb	Chr 6: 131.3 – 131.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000060140 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032899 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, Zeng L, Dai J, Wu Q, Gu S, Xie Y, Mao Y (Jul 2003). "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1". Mol Biol Rep. 30 (2): 91–6. doi:10.1023/A:1023934017174. PMID 12841579.
6. "Entrez Gene: STYK1 serine/threonine/tyrosine kinase 1".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu L, Yu XZ, Li TS, et al. (2004). "A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice". Cancer Res. 64 (10): 3491–9. doi:10.1158/0008-5472.CAN-03-2106. PMID 15150103.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Amachika T, Kobayashi D, Moriai R, et al. (2007). "Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers". Lung Cancer. 56 (3): 337–40. doi:10.1016/j.lungcan.2007.01.002. PMID 17298854.