CSPG5

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.[5][6]

CSPG5
Identifiers
Aliases	CSPG5, NGC, chondroitin sulfate proteoglycan 5
External IDs	OMIM: 606775 MGI: 1352747 HomoloGene: 4795 GeneCards: CSPG5
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 47,562,238 bp[1] End 47,580,792 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 110,243,783 bp[2] End 110,262,576 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • growth factor activity Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • cell membrane • integral component of plasma membrane • extracellular region • cell surface • lysosomal lumen • endoplasmic reticulum • Golgi lumen • Golgi-associated vesicle membrane • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane Biological process • cell differentiation • chondroitin sulfate biosynthetic process • modulation of chemical synaptic transmission • intracellular transport • nervous system development • multicellular organism development • chondroitin sulfate catabolic process • regulation of growth • dermatan sulfate biosynthetic process • regulation of receptor activity • trans-synaptic signaling, modulating synaptic transmission • regulation of synaptic vesicle exocytosis • cytoskeleton organization • glial cell projection elongation • positive regulation of substrate adhesion-dependent cell spreading • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10675	29873
Ensembl	ENSG00000114646	ENSMUSG00000032482
UniProt	O95196	Q71M36
RefSeq (mRNA)	NM_006574 NM_001206942 NM_001206943 NM_001206944 NM_001206945	NM_001166273 NM_013884
RefSeq (protein)	NP_001193871 NP_001193872 NP_001193873 NP_001193874 NP_006565	NP_001159745 NP_038912
Location (UCSC)	Chr 3: 47.56 – 47.58 Mb	Chr 9: 110.24 – 110.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CSPG5 has been shown to interact with GOPC.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114646 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032482 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res. 32 (4): 313–22. doi:10.1016/S0168-0102(98)00098-4. PMID 9950058.
6. "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
7. Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. United States. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.

Further reading

• Ichihara-Tanaka K, Oohira A, Rumsby M, Muramatsu T (2006). "Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells". J. Biol. Chem. 281 (41): 30857–64. doi:10.1074/jbc.M602228200. PMID 16901907.
• Aono S, Tokita Y, Yasuda Y, et al. (2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain". J. Neurosci. Res. 83 (1): 110–8. doi:10.1002/jnr.20698. PMID 16299773.
• Kinugasa Y, Ishiguro H, Tokita Y, et al. (2004). "Neuroglycan C, a novel member of the neuregulin family". Biochem. Biophys. Res. Commun. 321 (4): 1045–9. doi:10.1016/j.bbrc.2004.07.066. PMID 15358134.
• Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• Human CSPG5 genome location and CSPG5 gene details page in the UCSC Genome Browser.