Fyn-related kinase

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[5][6]

FRK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM: 606573 MGI: 103265 HomoloGene: 48065 GeneCards: FRK
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 115,931,149 bp[1] End 116,060,891 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 34,483,399 bp[2] End 34,611,278 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948 protein binding • receptor binding • ATP binding • non-membrane spanning protein tyrosine kinase activity • protein tyrosine kinase activity Cellular component • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • intracellular • extracellular exosome • extracellular region • cell nucleus • nucleoplasm • cytoplasm • azurophil granule lumen • specific granule lumen • cytosol Biological process • cell differentiation • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of transcription from RNA polymerase II promoter • protein phosphorylation • peptidyl-tyrosine autophosphorylation • innate immune system • negative regulation of cell proliferation • neutrophil degranulation • cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2444	14302
Ensembl	ENSG00000111816	ENSMUSG00000019779
UniProt	P42685	Q922K9
RefSeq (mRNA)	NM_002031	NM_001159544 NM_010237 NM_001358769
RefSeq (protein)	NP_002022	NP_001153016 NP_034367 NP_001345698
Location (UCSC)	Chr 6: 115.93 – 116.06 Mb	Chr 10: 34.48 – 34.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[6]

Interactions

FRK has been shown to interact with retinoblastoma protein.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
6. "Entrez Gene: FRK fyn-related kinase".
7. Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Further reading

• Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. doi:10.3727/096504003108748438. PMID 12725532.
• Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18): 3969–72. PMID 7664264.
• Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
• Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int. J. Cancer. 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567.
• Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease". Neurosci. Lett. 360 (1–2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.