EPHA8

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.[5][6]

EPHA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs	OMIM: 176945 MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 22,563,489 bp[1] End 22,603,595 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 136,929,419 bp[2] End 136,956,816 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • GPI-linked ephrin receptor activity • receptor tyrosine kinase • transmembrane signaling receptor activity • transmembrane-ephrin receptor activity Cellular component • integral component of membrane • endosome • cell projection • early endosome membrane • membrane • integral component of plasma membrane • cell membrane • neuron projection • cytoplasm • receptor complex Biological process • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • multicellular organism development • protein phosphorylation • cell adhesion • peptidyl-tyrosine phosphorylation • substrate-dependent cell migration • autophosphorylation • axon guidance • neuron projection development • regulation of cell adhesion • regulation of cell adhesion mediated by integrin • neuron remodeling • positive regulation of phosphatidylinositol 3-kinase activity • ephrin receptor signaling pathway • positive regulation of MAPK cascade • cellular response to follicle-stimulating hormone stimulus • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2046	13842
Ensembl	ENSG00000070886	ENSMUSG00000028661
UniProt	P29322	O09127
RefSeq (mRNA)	NM_001006943 NM_020526	NM_007939
RefSeq (protein)	NP_001006944 NP_065387	NP_031965
Location (UCSC)	Chr 1: 22.56 – 22.6 Mb	Chr 4: 136.93 – 136.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.[6]

Interactions

EPHA8 has been shown to interact with FYN.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000070886 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID 1648701.
6. "Entrez Gene: EPHA8 EPH receptor A8".
7. Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta". Curr. Opin. Neurobiol. 8 (1): 117–27. doi:10.1016/S0959-4388(98)80015-9. PMID 9568399.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly. Int. Rev. Cytol. International Review of Cytology. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683.
• Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
• Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist : A Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
• Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands". Oncogene. 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID 9053851.
• Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors". EMBO J. 16 (11): 3106–14. doi:10.1093/emboj/16.11.3106. PMC 1169929. PMID 9214628.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands". Mol. Cell. Neurosci. 9 (5–6): 331–2. doi:10.1006/mcne.1997.0630. PMID 9361271.
• Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.