TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.[5][6]

TYRO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RHF
Identifiers
Aliases	TYRO3, BYK, Dtk, RSE, Sky, Tif, Etk-2, Rek, TYRO3 protein tyrosine kinase
External IDs	OMIM: 600341 MGI: 104294 HomoloGene: 4585 GeneCards: TYRO3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,557,675 bp[1] End 41,583,589 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.97 cM Start 119,797,733 bp[2] End 119,818,104 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • virus receptor activity • kinase activity • phosphatidylinositol 3-kinase binding • GO:0001948 protein binding • protein heterodimerization activity • ATP binding • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity • Wnt-protein binding Cellular component • integral component of membrane • nuclear envelope • endoplasmic reticulum membrane • membrane • cell membrane • integral component of plasma membrane • cell nucleus • cell surface • cytoplasm • receptor complex Biological process • vagina development • phosphorylation • negative regulation of lymphocyte activation • protein phosphorylation • viral entry • phosphatidylinositol 3-kinase signaling • autophosphorylation • GO:0022415 viral process • signal transduction • natural killer cell differentiation • cell adhesion • negative regulation of innate immune response • spermatogenesis • platelet activation • forebrain cell migration • apoptotic cell clearance • substrate adhesion-dependent cell spreading • peptidyl-tyrosine phosphorylation • ovulation cycle • negative regulation of neuron apoptotic process • platelet aggregation • neuron cellular homeostasis • protein kinase B signaling • negative regulation of toll-like receptor signaling pathway • secretion by cell • negative regulation of inflammatory response • neuropeptide signaling pathway • negative regulation of signal transduction • Wnt signaling pathway • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7301	22174
Ensembl	ENSG00000092445	ENSMUSG00000027298
UniProt	Q06418	P55144
RefSeq (mRNA)	NM_006293 NM_001330264	NM_001290800 NM_019392
RefSeq (protein)	NP_001317193 NP_006284	NP_001277729 NP_062265
Location (UCSC)	Chr 15: 41.56 – 41.58 Mb	Chr 2: 119.8 – 119.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TYRO3 has been shown to interact with:

• GAS6,[7][8] and
• PIK3R1[9]

References

1. GRCh38: Ensembl release 89: ENSG00000092445 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027298 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (March 1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890.
6. "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase".
7. Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.
8. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (November 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.
9. Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood. 95 (2): 633–8. PMID 10627473.

Further reading

• Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603.
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495.
• Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC, Crosier PS (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors. 11 (2): 137–44. doi:10.3109/08977199409001055. PMID 7857658.
• Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene. 9 (3): 699–705. PMID 8108112.
• Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene. 9 (3): 975–9. PMID 8108143.
• Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA, Guida LC, Nicholls RD, Alitalo K (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene. 134 (2): 289–93. doi:10.1016/0378-1119(93)90109-G. PMID 8262388.
• Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.
• Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. PMID 8641360.
• Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.
• Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T, Ohno K, Takashima S, Onodera K (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell. 88 (1–2): 45–54. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267.
• Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood. 95 (2): 633–8. PMID 10627473.
• Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229.
• Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883.
• Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.
• Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779.
• Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y (2006). "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMC 1617303. PMID 17005688.